11 Jul 2019

Postdoctoral Research Assistant in Mathematical Modelling of Thymus Development

Grade 7: salary £32,236 – £39,609 p.a.
We invite applications for a Postdoctoral Research Assistant position to work with Professor Jon Chapman at the Mathematical Institute, University of Oxford. This is a 30 month fixed-term position, part of a large multidisciplinary project funded by The Wellcome Trust, and is available for an immediate start.

The overall aim of the project is to create a fully functional thymus in the lab, by using stem cell technology together with tissue engineering. To achieve this we will combine cutting-edge stem cell biology with biomaterials engineering and advanced mathematics. This holder of this position will develop quantitative mathematical models of thymus development, informed by experimental results and guiding the tissue engineering approaches. A wide range of mathematical ideas will be explored. A network analysis of gene expression data will be used to identify key checkpoints associated with cell differentiation. This will be used to develop and inform population dynamics (ordinary differential equation) models of cell growth and differentiation. In turn these will be extended to include spatial effects such as cell-cell and cell-substrate signalling to develop partial differential equation models of tissue development. The analysis of these models will involve a combination of asymptotic and numerical methods.

Candidates should be familiar with either differential equations and asymptotic methods, or network analysis and statistical methods, and be prepared to learn techniques they are unfamiliar with.

The successful candidate will also be given the opportunity to undertake teaching which will not exceed 3 hours per week for 24 weeks per annum.

Please direct informal enquiries to the Recruitment Administrator (email: vacancies@maths.ox.ac.uk), quoting vacancy reference141548.

Applicants should read the job description before writing their application. You will be required to upload a letter setting out how you meet the selection criteria, a curriculum vitae including full list of publications, a statement of research interests and the contact details of two referees as part of your online application. (NOTE: Applicants are responsible for contacting their referees and making sure that their letters are received by the closing date).

Applications for this vacancy are to be made online. To apply for this post and for further details, including the job description and selection criteria, please click on the link below:


Only applications received before 12:00 noon UK time on Friday 2nd August 2019 can be considered.

Committed to equality and valuing diversity.